COPE and ANFF-Q Synthetic and Purification Facilities

Synthetic and purifications faciltities at COPE and the ANFF-Q are comprised of the following instruments:



Heidolph Laborota 4000 Efficient


This is a bench top Rotary Evaporator, equipped with standard functions.  The equipment has convenient large dial controls for adjustment of rotation speed (from 20 to 270 rpm) and heating bath temperature (heating for water between 20oC - 180oC.)  The set bath temperature is displayed digitally with an accuracy of approximately 1oC.  For operation, apparatus is fitted with a vacuum pump capable of reaching a vacuum of 5 mbar, maintaining set vacuum to 5 mbar.


Rotational-Vacuum-Concentrator, Christ Freeze Dryer BETA 1-8 LD plus


This instrument is used to dry compounds at low temperatures via the use of vacuum.  Through sublimation, freeze-drying (lyophilisation) allows the extraction of water by directly converting ice to its vapor phase.  Lyophilisation remains one of the gentlest methods for drying inorganic materials, as the process has little to no effect on the surface properties of particles.


Sigma 2 - 5 Centrifuge


The centrifuge is used to allow the separation of liquids of different density or separate solid and liquid if the solid is a suspension of fine particles in the liquid.  A variety of reduction inlets and multiple carriers for a variety of different tubes (usually plastic or glass test tubes) can be used.  It has a simple 2-knob pre-selection speed/RCF and time.  A short operation period can be displayed in the time unit of seconds.  Electronically regulated times of up to 30 minutes or continual run can be selected.  It has an efficient electrical brake for short deceleration and soft stop for sensitive sedimentations.  This centrifuge has a double cover closing and locking mechanism according to the German accident prevention regulation (VBG 7z).  A LED-indicator signalizes when the rotor has stopped and the lid may be opened.  Speed/RCF and time are indicated.  The product is compliant with national and international safety regulations (IEC 1010, CE).  No. 10130 for 230 VAC 50+60 Hz.


Medium Pressure Liquid Chromatography (MPLC)


This instrument allows the separation of mixtures of substances that cannot be resolved by atmospheric chromatography.  A wide range of organic solvents, as well as salt solutions can be used.  Different types of columns are available and the maximum pressure as high as 50 bar can be achieved, which gives optimum separation results for a broad range of applications.


Stirred High Pressure PARR Reactors



The two High Pressure Parr Reactors (bombs) at the COPE Laboratories are available for the synthesis of deuterated compounds for materials research by isotope exchange.  The reactors can use either hydrogen or deuterium gas at 50 psi.  Deuterated surfactants, long chain fatty acids and phospholipids are used in neutron scattering studies to increase contrast in neutron reflectivity and small angle scattering measurements.  Deuterium labeled compounds have played an important role in biological and chemical research - investigation of biosynthetic pathways, the catalytic mechanisms of enzymes, analysis of secondary and tertiary structures of biomolecules, analysis of drug metabolism, and chemical reaction mechanisms and kinetics - to state a few.  Due to their transparency in the infrared wavelength region, deuterium-labeled polymers are now new material for wave guides in optical communication systems.


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